Facioscapulohumeral Muscular Dystrophy Diagnosis Using Hierarchical Clustering Algorithm and K-Nearest Neighbor Based Methodology

Abstract

The genetic diagnosis of neuromuscular disorder is an active area of research. Microarrays are used to detect the changes in genes for the accurate diagnosis. Unfortunately, the number of genes in gene expression data is very large as compared to number of samples. The number of genes needs to be reduced for correct diagnosis. In the present paper, the authors have made an intelligent integrated model for clustering and diagnosis of neuromuscular diseases. Wilcoxon signed rank test is used to preselect the genes. K-means and hierarchical clustering algorithms with different distance metric are employed to cluster the genes. Three classifiers namely linear discriminant analysis, quadratic discriminant analysis and k-nearest neighbor are used. For the employment of integrated techniques, a balanced facioscapulohumeral muscular dystrophy dataset is taken. A comparative analysis of the above integrated algorithms is presented which demonstrate that the integration of cosine distance metric hierarchical clustering algorithm with k-nearest neighbor has given the best performance measures.