As a favorite sport of teachers and students, long-distance running can enhance physical fitness. However, due to nonstandard movements in sports, teachers and students get injured psysically. Taking the prevention of long-distance running injuries of teachers and students in colleges and universities as the research goal, this article investigates the teachers and students of a physical education college in Shanxi Province by means of questionnaire survey, counts the functional indexes of teachers and students in long-distance running for one year and analyzes the injuries. The results show that the injury rate of teachers and students is 45.5%; Teachers and students with only one injury are the most, and knee injuries are the most common, with a mild injury rate of 60.98% and concentrated in November-December and June-July. The main reasons for the injuries of teachers and students are poor physical fitness, insufficient warm-up, and poor sports equipment. Through full warm-up exercise and adequate rest, common injuries in long-distance running can be effectively prevented.