This study determined the factors that influenced the usability of a mobile-based intelligent agent called “AskRed.” The design-related factors were evaluated in terms of performance, accuracy, responsiveness, aesthetics, and completeness. The usability of the software was determined in terms of satisfaction and intention to re-use the software. The software received favorable ratings from the students. Experts' software evaluation recommended strengthening the design of the intelligent agent in terms of security, performance, completeness, and ease-of-use. Multiple regression analyses showed that performance and completeness influenced satisfaction and intention to re-use. Aesthetics and responsiveness influenced satisfaction but not intention to re-use. Responsiveness had a negative impact on satisfaction. The predictive powers of the regression equations are 58% and 73%. This study provided empirical evidence on the predictors of usability of an intelligent agent used in a university setting.