Abstract
Native to the Mediterranean and southwest Asia, Celtis australis is used in folk medicine to treatment of many diseases such as peptic ulcer, diarrhea, dysentery, pain, and colic. However, there are very few studies on the effects of this species on cancer. We report for the first time the cytotoxic and genotoxic properties of C. australis on the human ovarian cancer cell line A2780.
In the study, C. australis extract prepared in ethanol/phosphate buffer was applied to A2780 cells. The change in viability level in A2780 cells after treatment was determined by MTT assay and DNA damage was determined by single-cell gel electrophoresis (Comet) analysis.
Our results showed that plant extract application at doses above 200 µg/ml significantly decreased A2780 cell viability (p
Reference23 articles.
1. Jiramongkol Y, Lam EW. FOXO transcription factor family in cancer and metastasis. Cancer Metastasis Rev. 2020;39(3):681-709.
2. Wild C, Weiderpass E, Srewart B. World cancer report. International agency for research on cancer: WHO; 2020.
3. Kara F, Keskinkılıç B. Türkiye kanser istatistikleri 2017 Ankara: T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü; 2021 [updated 17.11.2021. Available from: https://hsgm.saglik.gov.tr/depo/birimler/kanser-db/istatistik/Turkiye_Kanser_Istatistikleri_2017.pdf.
4. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.
5. Romero-Sandoval EA, Fincham JE, Kolano AL, Sharpe BN, Alvarado-Vazquez PA. Cannabis for chronic pain: Challenges and considerations. Pharmacotherapy. 2018;38(6):651-62.