Abstract
The Fumaria L. species (Papaveraceae), is known colloquially as “Şahtere”. This species, which has been proven to contain significantly rich components, is used by people to treat a number of different diseases. This study investigated the cytotoxic effects of the methanolic extracts of above-ground portions of Fumaria asepala Boiss. and Fumaria schleicheri Soy.-Will. subsp. microcarpa Boiss. ex Hausskn. taxons against Beas-2B, sh-sy5, HCT116 and A549 cell lines. The changes in cancer cell vitality were identified using the 3-(4.5-dimethylthiazol -2-il)-2.5-diphenyltetrazolium bromide (MTT). While the results showed that F. asepala and F. schleicheri subsp. microcarpa's methanolic extracts presented a meaningful decrease in the vitality of colon (HCT-116) cancer cells, no cytotoxic effect was achieved on lung (A549) cancer and brain (sh-sy5) cancer cells. Also, the herbal extracts did not create any toxic effect on healthy lung cells (Beas-2B).
Reference33 articles.
1. Aksoy C, Yücecan S, Çiftçi N, Tayfur M, Akgün B, Taşcı N. Local plants used for treatment in cancer disease. J. of Nutr. and Dietetics. 1988;17(1): 111-120.
2. Yılmaz B. Investigation of Antitumoral Activity of Plant Extracts Collected from Various Regions [Master Thesis]. Tekirdağ: Namık Kemal University, Institute of Health Science; 2018.
3. Çoban T, Çitoǧlu G, Sever B, İşcan M. Antioxidant activities of plants used in traditional medicine in Türkiye. Pharmaceutical Biology. 2003;41(8):608-613.
4. Goncalves S, Romano A. The medicinal potential of plants from genus Plantago (Plantaginaceae). Industrial Crops and Products. 2016;83(1):213-226.
5. Baydar H. Tıbbi, Aromatik ve Keyf Bitkileri Bilimi ve Teknolojisi. 1st ed. Türkiye: Suleyman Demirel University Publications; 2005;111-115.