Affiliation:
1. ATATURK UNIVERSITY, HORASAN VOCATIONAL SCHOOL
2. AKSARAY ÜNİVERSİTESİ, AKSARAY TEKNİK BİLİMLER MESLEK YÜKSEKOKULU
Abstract
Arsenic is a very dangerous metal that is widely distributed in the environment as a result of anthropogenic and natural processes. On the other hand, it is thought that treatment with natural flavonoids may protect against arsenic toxicity. Carvacrol (CRV) is a naturally occurring phenolic compound with anti-inflammatory, anti-apoptotic, and antioxidant properties. This study aims to investigate the protective effects of CRV on sodium arsenite (SA)-induced intestinal toxicity. For this purpose, rats were randomly divided into five groups and administered SA and CRV orally for 14 days. The data indicate that when SA is administered, lipid peroxidation increase and antioxidant enzyme activities decrease. The administration of CRV ameliorated this impairment in the antioxidant defense system. Examining the expression levels of NF-kB and IL-1 revealed that inflammation increased with SA application but decreased with CRV administration. Moreover, the expression levels of Caspase-3 and Apaf1 increased in rats treated with SA, whereas the severity of apoptosis decreased when CRV was administered. In light of these findings, it is possible to state that CRV protects tissues from damage by presenting antioxidant, anti-inflammatory, and anti-apoptotic effects in SA-induced intestinal toxicity.
Subject
General Earth and Planetary Sciences,General Environmental Science
Reference39 articles.
1. Nikravesh M, Mahdavinia M, Neisi N, Khorsandi L, Khodayar MJ. Citicoline ameliorates arsenic-induced hepatotoxicity and diabetes in mice by overexpression of VAMP2, PPAR-gamma, As3MT, and SIRT3. Pestic Biochem Physiol. 2023;192:105391.
2. Anetor JJ, Wanibuchi H, Fukushima S. Arsenic exposure and its health effects and risk of cancer in developing countries: Micronutrients as host defence. Asian Pac J Cancer P. 2007;8(1):13-23.
3. Liu RQ, Kong SQ, Shao YX, Cai DW, Bai B, Wei XG, et al. Chorover, Mechanisms and health implications of toxicity increment from arsenate-containing iron minerals through in vitro gastrointestinal digestion. Geoderma. 2023;432:116377.
4. Brown KG, Ross GL. Arsenic, drinking water, and health: A position paper of the American Council on Science and Health. Regul Toxicol Pharm. 2002;36(2):162-174.
5. Caglayan C, Demir Y, Kucukler S, Taslimi P, Kandemir FM, Gulcin I. The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach. J Food Biochem. 2019;43(2): e12720.