Effect of repeated sodium valproate and topiramate administration on mania-like behaviors induced by methylphenidate in mice
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Published:2022-12-30
Issue:
Volume:
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ISSN:1689-0035
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Container-title:Acta Neurobiologiae Experimentalis
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language:
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Short-container-title:Acta Neurobiol Exp (Wars)
Author:
Gon�alves Priscila Samaha,Pesquero Bruno Oliveira,Valentin Daniel Taques,Monteiro Pereira Vivian Cristhiane,Andreatini Roberto
Abstract
Novel and effective treatments for mania are needed, and well-validated animal models are important to reach this goal. The
psychostimulant-induced hyperactivity is the most frequently animal model of mania used. Although this model is validated
pharmacologically using mood stabilizers, data about its predictive validity with negative controls (i.e., drugs that are clinically
ineffective in treating mania) are lacking. The present study evaluated the effects of the repeated administration of a clinically
effective drug (sodium valproate) and clinically ineffective drug (topiramate) on methylphenidate (MPH)-induced manic-like
behaviors in Swiss mice in the behavioral pattern monitor (BPM). Methylphenidate increased locomotor activity and center
activity in the BPM. Valproate attenuated the effect of MPH on locomotor and general activity, with no effect on center
activity. Topiramate did not affect any MPH-induced manic-like behaviors. Methylphenidate did not change exploratory
activity (rearing or nose poking). These results support the predictive validity of MPH-induced hyperactivity for screening
antimanic-like drugs.
Publisher
The Nencki Institute of Experimental Biology, Polish Academy of Sciences
Subject
General Medicine,General Neuroscience