Allele expression of Peroxisome-gamma2 proliferation activator receptor gene in overweight eldery patients with ischemic heart disease

Abstract

It is known that about a third of the world's population suffers from obesity. Peroxisome activation receptors, namely, the γ2 promoter, is abundantly locatein adipose tissue, regulating adipogenesis, lipid accumulation, and glucose homeostasis. The aim of this investigations was to study the expression features of the PPARγ2 gene alleles in elderly patients with comorbid conditions such as obesity and ischemic heart disease. From 2017 to 2019 in "Clinical Hospital № 29 named. N.E. Bauman” (Moscow) 140 patients of both sexes (54.3% men and 45.7% women) aged 60-89 years were examined by us. The main group included 70 pts with ischemic heart disease, and the control group included 70 pts without it. Pro12 allele carriage in the main group had 85%, and the Ala12 allele - 15%. Pro12Ala and Ala12Ala genotypes, Ala12 allele were detected more often in patients with ischemic heart disease than in the control group (p=0.0008 and p=0.0003, respectively). Pro12Ala genotypes carriage (OR=2.02, CI = 1.28-3.19, p=0.003) and Ala12Ala (OR=2.002, CI = 1.32-3.04, p=0.0006) of the Ala12 gene PPARγ2 increases the risk of developing ischemic heart disease by 2 times. The revealed features of the expression of PPARγ2 gene alleles in elderly patients with obesity and ischemic heart disease e confirm the ability of nuclear PPARs to control development, differentiation, metabolic homeostasis and reproduction. To clarify the role of various genotypes of the PPARy2 gene in the regulation of lipid metabolism and angiogenesis in the discussed comorbid conditions in elderly patients may help to identify new methods of it treatment.