Evolutionary-histological studies of the doctor of medicine Vera Mikhailovna Danchakova

Abstract

The historical article presents material that analyzes the contributor from the first female histologists V.M. Danchakova in the study of problems of evolutionary histology and questions of normal and pathological histogenesis. Vera Mikhailovna Danchakova is a student of Professor A.A. Maksimov, the first woman, who defended a histological dissertation at the Imperial Military Medical Academy (1907). In foreign literature, her work is referred to as pioneering in the study of cells, which are now called stem cells. V.M. Danchakova made a significant contribution to the study of the evolutionary aspects of histogenesis of tissues with various cambial properties, for the first time showed the extragonadal origin of primary germ cells using the example of birds, and obtained new additional experimental data confirming A.A. Maksimov's unitary theory of hematopoiesis. Thanks to her research, the possibility of malignancy of stem and progenitor cells was shown for the first time. V.M. Danchakova was prompted by the study of generative cells (primary germ cells, gonocytes), as well as the influence of male and female sex hormones on sex differentiation in embryo-genesis. The results of her experiments using the method of tissue and cell cultures formed the basis for the development of the doctrine of the immune response "graft versus host”.