Gabapentin for Tinnitus: A Systematic Review

Author:

Aazh Hashir1,El Refaie Amr2,Humphriss Rachel2

Affiliation:

1. Royal Surrey County Hospital NHS Foundation Trust, Guildford, United Kingdom

2. University of Bristol, Bristol, United Kingdom

Abstract

Purpose The main aim of this study was to assess the effect of gabapentin on tinnitus via a systematic review. Method An electronic search of literature as well as a hand search were conducted. Only double-blind randomized controlled trials (RCTs) that met all of the inclusion criteria were included in this review. The Cochrane Collaboration tool for risk of bias assessment was used to investigate the validity of the included studies. Meta-analysis was not appropriate due to inadequate details in reporting the data in the included studies. Hence, qualitative synthesis and interpretation of the data were carried out. Results Two studies that met the inclusion criteria were included in the review. Fourteen studies were excluded. There were substantive within-study clinical heterogeneities with regard to the baseline tinnitus handicap scores, duration of tinnitus, and severity of hearing loss in the included double-blind RCTs. Conclusion The authors of both studies reported that gabapentin was not superior to placebo in their primary outcomes. However, following the assessment of risk of bias and within-study clinical heterogeneities, this review concludes that there is insufficient evidence regarding the effect of gabapentin on tinnitus.

Publisher

American Speech Language Hearing Association

Subject

Speech and Hearing

Reference53 articles.

1. Gabapentin effectiveness on the sensation of subjective idiopathic tinnitus: A pilot study;Bakhshaee M.;European Archives of Otorhinolaryngology,2008

2. Mechanisms of tinnitus generation;Bauer C. A.;Current Opinion in Otolaryngology & Head and Neck Surgery,2004

3. Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model;Bauer C. A.;Journal of the Association for Research in Otolaryngology,2001

4. Effect of gabapentin on the sensation and impact of tinnitus;Bauer C. A.;Laryngoscope,2006

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