Affiliation:
1. Purdue University, West Lafayette, IN
Abstract
Purpose
Voice problems are reported as a frequent side effect of inhaled combination (IC) treatments. The purpose of this experimental study was to investigate whether IC treatments are detrimental to phonation. We hypothesized that IC treatment would significantly increase phonation threshold pressure (PTP) and perceived phonatory effort (PPE), whereas sham treatment would not.
Method
Fourteen healthy adults participated in a repeated-measures design in which they received IC and sham treatments in counterbalanced order. PTP and PPE were measured prior to treatments, immediately following treatments, and at 1 and 2 hr following treatments.
Results
IC treatment increased PTP, but sham treatment did not. The increase in PTP was maintained for a 2 hr period following administration. PPE ratings were not significantly correlated with PTP.
Conclusions
IC treatments can have acute, adverse effects on phonation. Detrimental phonatory effects were elicited in participants with no self-reported voice problems. IC treatments are being increasingly prescribed across the lifespan. The current data increase our understanding of the nature of phonatory deterioration associated with IC treatment and lay the groundwork for increased research effort to develop IC treatments that effectively control respiratory disease while minimizing an adverse effect on phonation.
Publisher
American Speech Language Hearing Association
Subject
Speech and Hearing,Linguistics and Language,Language and Linguistics
Reference46 articles.
1. American Lung Association. (2008). Data and statistics. Retrieved January 24 2009 from http://www.lungusa.org/site/c.dvLUK9O0E/b.33347/k.AC09/Data__Statistics.htm
2. The effect of inhaled steroids on the upper respiratory tract;Babu S.;Journal of Laryngology and Otology,1988
3. How do corticosteroids work in asthma?;Barnes P. J.;Annals of Internal Medicine,2003
4. Prevalence of pharyngeal and laryngeal complications in adult asthmatics using inhaled corticosteroids;Bhalla R.;Journal of Laryngology and Otology,2008
5. What role for inhaled steroids in chronic asthma?;Busse W. W.;Chest,1993
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献