Author:
Queiroz Aristides Cheto de
Abstract
A previous publication documented a sarcomatous transformation observed in a cell line derived from a rat lymphoma growing in monolayer culture. (9) The morphological and cytogenetic changes found, suggested the presence of virus and the differentiation of the malignant lymphoblasts toward malignant histiocytes in culture. The present paper describes, under the electron microscope the structural features of the original tumor, of the cells growing in culture and of the derived sarcoma. This study will serve to complement the prior observations.
Publisher
Revista Brasileira De Cancerologia (RBC)
Reference13 articles.
1. Bernhard, W. — Ultrastructural aspects of the normal and pathological nucleolus in mammalian cells. Natl. Câncer Inst. Monograph 23:13-38,1966.
2. Cohn, Z. A., Fedorko, M. E. and Hirsch, J. G. — The in vitro differentiation of mononuclear phagocytes. IV — The ultrastructure of macrophage differentiation in the peritoneal cavity and in culture. V — The formation of macrophage lysosomes. J. Exp. Med. 123: 747-756,1966.
3. Clarke M. A. – Specialized intercelular junctions in tumor cells. An electron microscope study of mouse sarcoma cells. Anat. Rec. 166: 199-206,1970.
4. Davidson, E. H. — Differentiation in monolayer culture cells. Advan. Genet. 12: 143-280,1964.
5. Devis, R. and James, D. W. – Close associations between adult guinea-pig fibroblasts in tissue culture, studied with the electron microscope. J. Anat. (London) —98: 63-68,1964.