Correlation between Activity and Molecular Structure around the Active Center of Cytochrome P450cam Conjugates

Author:

Oshiba Yuhei1,Tamaki Takanori1,Ohashi Hidenori1,Hirakawa Hidehiko2,Yamaguchi Satoshi2,Nagamune Teruyuki23,Yamaguchi Takeo1

Affiliation:

1. Chemical Resources Laboratory, Tokyo Institute of Technology

2. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo

3. Department of Bioengineering, School of Engineering, The University of Tokyo

Publisher

Society of Chemical Engineers, Japan

Subject

General Chemical Engineering,General Chemistry

Reference20 articles.

1. Abuchowski, A., J. R. Mccoy, N. C. Palczuk, T. van Es and F. F. Davis; “Effect of Covalent Attachment of Polyethylene-Glycol on Immunogenicity and Circulating Life of Bovine Liver Catalase,” J. Biol. Chem., 252, 3582–3586 (1977)

2. Busby, W. F. Jr., J. M. Ackermann and C. L. Crespi; “Effect of Methanol, Ethanol, Dimethyl Sulfoxide, and Acetonitrile on in Vitro Activities of cDNA-Expressed Human Cytochromes P-450,” Drug Metab. Dispos., 27, 246–249 (1999)

3. De, P., M. Li, S. R. Gondi and B. S. Sumerlin; “Temperature-Regulated Activity of Responsive Polymer–Protein Conjugates Prepared by Grafting-From via RAFT Polymerization,” J. Am. Chem. Soc., 130, 11288–11289 (2008)

4. Dunn, A. R., I. J. Dmochowski, A. M. Bilwes, H. B. Gray and B. R. Crane; “Probing the Open State of Cytochrome P450cam with Ruthenium-Linker Substrates,” Proc. Natl. Acad. Sci. U.S.A., 98, 12420–12425 (2001)

5. Furge, L. L. and F. P. Guengerich; “Cytochrome P450 Enzymes in Drug Metabolism and Chemical Toxicology,” Biochem. Mol. Biol. Educ., 34, 66–74 (2006)

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