Synthesis of novel 2-amino-5-arylazothiazol derivatives and their biological impacts: Assessment of toxicity and antioxidant enzymes activities

Abstract

<p>The reactivity study of both the amino group and the aryl substituent of the newly synthesized 2-amino-5-(4-acetylphenylazo)-thiazole compound and its derivatives <em>via</em> various electrophilic reagents were performed to obtain the expected new bioactive chalcone, imine and pyrazole-<strong> </strong>thiazolidine<strong> </strong>derivatives. The synthesized compounds were chemically elucidated by analytical and spectral methods, and biologically evaluated upon screening <em>in vitro</em> and <em>in vivo</em> for their toxicity and antioxidant activity based on liver function enzymes.</p>