Türkiye'deki Berberis türlerinin terapötik potansiyellerine ve güvenlik profillerine genel bir bakış

Abstract

The objective of this review is to present a comprehensive summary of the botanical descriptions, traditional uses, phytochemical properties, pharmacological activities, clinical studies, and safety of Berberis species that are naturally found in Turkey. According to our findings, people in Turkey use various Berberis species for both food and medicinal purposes. Fruits, roots, and flowers of Berberis crataegina are used to treat diarrhea, hemorrhoids, high blood sugar, and icterus. Berberis integerrima is used to treat hemorrhoids, and Berberis vulgaris is used to treat diabetes and hemorrhoids, as well as being used as an antipyretic, stomachic, appetizer, wound healer, and laxative. Berberis cretica is used for medicinal purposes among the people. Clinical research has indicated that berberine holds promise as a potential candidate for the treatment for various diseases, including diabetes, cancer, hypertension, obesity, and liver disease. Berberine is a promising natural agent with low toxicity that can be used in numerous clinical applications such as metabolic disorders, inflammation, and combined cancer therapy. While numerous studies have explored the pharmacological effects of Berberis vulgaris, research on other naturally occurring Berberis species in Turkey is lacking. For this reason, it is necessary to undertake comprehensive clinical studies regarding Berberis species that grow naturally in Turkey. Overall, the use of Berberis species for their therapeutic properties has great potential, and further research is needed to fully understand their pharmacological properties and to explore new formulations and derivatives. This will help to maximize the benefits of Berberis species in managing a wide spectrum of diseases in the human population.