Affiliation:
1. Veer Wajekar College, Panvel
2. Dr. Homi Bhabha State University, Mumbai
Abstract
In this we have carried out Frielander synthesis (modified Niementowski reaction) and Niementowski reaction for synthesis of quinozoline 4-(3H)-one derivatives and quinoline derivatives. The reaction of anthranillic acid, amides, diketones (Cyclisation) have been performed over organic clays as the catalyst, under solvent-less conditions using microwave irradiation as the energy source, obtaining the corresponding quinozoline derivatives. Reaction of anthranilic acid with acetyl acetone and ethyl acetoacetate (1:1) yields new compounds 3-methyl-6H-benzo[c][1,5]oxazocin-6-one and 3-methyl-3H-benzo[c][1,5]oxazocine-4,6-dione respectively. These reactions represent some examples of efficient microwave irradiation promoted organic condensation and cyclisation in which the reaction can be carried out in the open vessels by using organic clay as a catalyst and provides products with satisfactory yields and simple work up as greener approach
Reference18 articles.
1. [1] J. P. Michael, “Quinoline, quinazoline and acridone alkaloids,” Nat. Prod. Rep., vol22, pp. 627, 2005.
2. [2] W. L. F. Armarego, Fused Pyrimidines, Part 1: Quinazolines; Interscience: New York, 1967.
3. [3] K. Undheim, T. Benneche, In Comprehensive Heterocyclic Chemistry II, 6; Pergamon: Oxford, 1998.
4. [4] T. L. J. Gilchrist, “Synthesis of aromatic heterocycles,” Chem. Soc., Perkin Trans., vol 1, pp.2491-2515, 2001.
5. [5] T.L. J. Gilchrist, “Synthesis of aromatic heterocycles,” Chem. Soc., Perkin Trans., vol 1, pp. 2849-2866, 1999.