Floating Drug Delivery System

Abstract

Any drug delivery system is aimed to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non-toxic for a prolonged period. Recent pharmaceutical research and development focuses on the formulation of floating drug delivery system (FDDS). FDDS have low density systems that float over the gastric contents in stomach and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate due to buoyancy force. Various approaches such as low density systems , swelling and expanding systems, bioadhesive systems, high density systems or other delayed gastric emptying devices have been discovered. This review composition gives detailed information on the pharmaceutical basis of their design, advantages and disadvantages, ideal candidates, classification, methods of preparation, in vitro and in vivo evaluation parameters, etc.