An Efficient, Green Synthesis of Hemiaminals of Isatins using TBAF under Aqueous Reaction Media
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Published:2022-03-31
Issue:
Volume:
Page:9-13
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ISSN:2581-9429
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Container-title:International Journal of Advanced Research in Science, Communication and Technology
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language:en
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Short-container-title:IJARSCT
Author:
Pramod B Thakur 1, Rupashri K. Kadu 1, Ganesh A. Thakur 1, Raghunath A. Katkar 1
Affiliation:
1. Rayat Shikshan Sanstha’s, Mahatma Phule Arts, Science & Commerce College, Panvel, Raigad, India
Abstract
The synthesis of hemiaminals of isatin derivatives is described by the reaction of isatin with formaldehyde in the presence of TBAF in water at ambient temperature. The procedure is very simple, convenient, and efficient, which provides high yield of product. Additionally the method is applicable for both varieties of substituted isatins derivatives. Moreover, the environmentally benign nature of reaction media makes the procedure attractive alternative over earlier methods.
Publisher
Naksh Solutions
Reference31 articles.
1. (a) Liou, J. P.; Wu, C. Y.; Hsieh, H. P.; Chang, C. Y.; Chen, C. M.; Kuo, C. C.; Chang, J. Y. J. Med. Chem. 2007, 50, 4548; (b) Kemnitzer, W.; Drewe, J.; Jiang, S.; Zhang, H.; Crogan-Grundy, C.; Labreque, D.; Bubenick, M.; Attardo, G.; Denis, R.; Lamothe, S.; Gourdeau, H.; Tseng, B.; Kasibhatla, S.; Cai, S. X. J. Med. Chem.2008, 51, 417. 2. Mahfouz, N. M.; Omar, F. A.; Aboul-Fadl, T. Eur. J. Med. Chem. 1999, 34, 551. 3. Wiley-Interscience: New York, 2007. pp 1281-1283 4. Foster, R.;Young, D. J. Chem. Soc., Perkin Trans. 2, 1985, 1285. 5. (a) Smith, M. B.; March, J. March's Advanced Organic Chemistry; Wiley-Interscience: New York, 2007. pp 1281-1283;
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