Studies in Solute-Solute and Solute-Solvent Interaction of Some Substituted Ketimine Drugs in 75 % Dichloromethane Water Mixture under Different Temperature by Viscometric Technique

Abstract

The computation of densities, specific viscosities of 5- Bromo-2-hydroxy-4-chloro (p-methyl phenyl) ketimine (L1) and 5- Bromo-2-hydroxy-4-chloro (p-amino phenol) ketimine (L2) drugs in 75% (DCM + water) mixture at the temperature range (308 to 314 K) are reported. The investigational data shows, the effect of temperature on viscosity of solute in DCM + water mixtures which gives idea about the molecular interactions present in different solutions. Considerable molecular interactions have been observed between the substituted ketimines drugs and DCM + water mixture. The experimental data at different temperature range (308 to 314 K) are used to investigate thermodynamic properties such as free energy change (∆G), enthalpy change (∆H) and entropy change (∆S) of substituted ketimines drugs in 75% (DCM + water) mixture. The experimental data gives the idea about effect of temperature on the molecular interaction and structural changes in solute.