A Review on Bigel Novel Drug Delivery System

Abstract

Bigels are systems that are usually formed by mixing a hydrogel and an organogel: the aqueous phase is generally made of hydrophilic biopolymer through the organic phase comprise of a gelled vegetable oil because of the presence of an organogelator. The quantity of the gelling agent in every phase, the organogel/ hydrogel percentage, and the temperature of mixing and speed of each parameter need to be considered for bigel preparation. Bigels are chiefly beneficial drug delivery systems, which have been prepared for transdermal, buccal, and vaginal routes. Analytical studies and microscopical determination are the most reported characterization techniques. Bigel’s composition and distinguishing structure confer promising drug delivery aspects such as mucoadhesion, the capability to control drug release, and the probability of using both hydrophilic and lipophilic drugs in the same system.