Abstract
INTRODUCTION. Postmenopausal osteoporosis (PMO) accounts for up to 85 % of all cases of osteoporosis, complications of which — pathological fractures — lead to a decrease in quality of life and functionality, pain, severe psycho-emotional disorders, loss of ability to self-care, disability and an increased risk of death. Timely prescribed pathogenetic therapy for osteoporosis, including in patients undergoing medical rehabilitation, helps reduce the risk of developing osteoporotic fractures and prevent complications associated with them.
MAIN CONTENT OF THE REVIEW. The literature review analyzes 5 domestic and 47 foreign literary sources, on the basis of which a description of modern methods of treating PMO is made in order to reduce the risk of developing pathological fractures. Poor patient adherence to osteoporosis therapy is associated with low effectiveness of PMО treatment and an increased financial burden on the healthcare system — increased hospitalization rates and treatment costs. The infrequent dosing frequency and good tolerability of therapy help to increase adherence to oral supplements.
CONCLUSION. The review focused on the effectiveness and safety of the oral bisphosphonate ibandronic acid 150 mg once a month, the administration of which to women with PMO demonstrated good tolerability, ease of use and high efficiency, both in reducing the risk of fractures and in increasing bone mineral density, including long-term treatment periods — 5 years.
Publisher
National Medical Research Center For Rehabilitation And Balneology
Subject
Rehabilitation,Physical Therapy, Sports Therapy and Rehabilitation
Reference52 articles.
1. Белая Ж.Е., Рожинская Л.Я., Гребенникова Т.А. и др. Краткое изложение проекта федеральных клинических рекомендаций по остеопорозу. Остеопороз и остеопатии. 2020; 23(2): 4-21. https://doi.org/10.14341/osteo12710 [Belaya Z.E., Rozhinskaya L.Y., Grebennikova T.A. et al. Summary of the draft federal clinical guidelines for osteoporosis. Osteoporosis and Bone Diseases. 2020; 23(2): 4–21. (In Russ.) https://doi.org/10.14341/osteo12710 (In Russ.).]
2. Curtis E.M., Moon R.J., Harvey N.C., Cooper C. The impact of fragility fracture and approaches to osteoporosis risk assessment worldwide. Bone. 2017; 104: 29–38.
3. Меньшикова Л.В., Храмцова Н.А., Ершова О.Б. и др. Ближайшие и отдаленные исходы переломов проксимального отдела бедра у лиц пожилого возраста и их медико-социальные последствия (по данным многоцентрового исследования). Остеопороз и остеопатии. 2002; 1: 8–11. [Menshikova L.V., Khramtsova N.A., Ershova O.B. et al. Immediate and distant outcomes of proximal femur fractures in the elderly and their medical and social consequences (according to multicenter study). Osteoporosis and Bone Diseases. 2002; 1: 8–11. (In Russ.).]
4. Lesnyak O., Ershova O., Belova K. et al. Epidemiology of fracture in the Russian Federation and the development of a FRAX model. Archives of Osteoporosis.2012; 7: 67–73.
5. Марченкова Л.А., Макарова Е.В., Герасименко М.Ю., Васильева В.А. и др. Эффективность нового комплекса физической реабилитации с включением технологий механотерапии в улучшении показателей качества жизни пациентов с компрессионными переломами позвонков на фоне остеопороза. Физиотерапия, бальнеология и реабилитация. 2020; 19(1); 51–58. https://doi.org/10.17816/1681-3456-2020-19-1-8 [Marchenkova L.A., Makarova E.V., Gerasimenko M.Y. et al. The effectiveness of a new complex of physical rehabilitation with the inclusion of mechanotherapy technologies in improving quality of life in patients with osteoporotic vertebral fractures. Russian Journal of Physiotherapy, Balneology and Rehabilitation. 2020; 19(1); 51-58. https://doi.org/10.17816/1681-3456-2020-19-1-8 (In Russ.).]