Affiliation:
1. ORDU UNIVERSITY, SCHOOL OF MEDICINE
Abstract
Objective: We aimed to investigate the relationship of vitamin B12 and vitamin D with IL-4, IL-10 and TNF-Beta in obese patients. Methods: Serum IL-4, IL-10 and TNF-Beta levels were measured using kits based on the enzyme-linked immunosorbent assay (ELISA) principle. Results: The IL-10 level was found to be significantly lower in the low vitamin D group (p= 0.039). When vitamin B12 normal, vitamin B12 low and control groups were compared, a statistical difference was found between the groups in terms of IL-10 (p=0.002). As a result of post hoc analysis, the IL-10 level was found to be significantly lower in the vitamin B12 low group than in the vitamin B12 normal group (0.04). At the same time, vitamin B12 was statistically higher in the normal group (obesity positive) than in the control group (non-obese vit B12 normal) (p=0.001). A positive correlation was found between vitamin B12 and IL-10 (r= 0.203 p= 0.058). Conclusion: It has been shown that low levels of vitamin D and vitamin B12 in obese patients cause low levels of IL-10. It was also found that obesity caused an increase in IL-10 levels. No relationship was found between IL-4 and TNF-Beta and vitamin D and vitamin B12. Longer follow-up and studies in larger case populations are needed to better understand the effects of vitamin B12 and vitamin D on IL-4, IL-10 and TNF-Beta levels in obese patients.
Funder
Ordu University Scientific Research Projects Coordination Unit
Reference30 articles.
1. 1.Vakilian A, Razavi-Nasab SM, Ravari A, Mirzaei T, Moghadam-Ahmadi A, Jalali N et al. Vitamin B12 in Association with Antipsychotic Drugs Can Modulate the Expression of Pro-/Anti-Inflammatory Cytokines in Alzheimer Disease Patients. Neuroimmunomodulation 2017;24(6):310-319.
2. 2.Akdoğan M, Yöntem M. Sitokinler. Online Türk Sağlık Bilimleri Dergisi 2018; 3(1):36-45.
3. 3. Sergei I. Grivennikov, Florian R. Greten and Michael Karin. Immunity, Inflammation, and Cancer. Cell. 2010;140(6):883–899.
4. 4. Zhang J-M, An J. Cytokines, Inflammation and Pain. International Anesthesiology Clinics. 2009;45(2):27-37.
5. 5.Kartalcı Ş, Gönenir Erbay L, Porgalı Zayman E, Otlu Ö, Bay Karabulut A, Kartalcı G. IL-4, TGF-β, NF-κB and MPO levels in Patients with Treatment Resistant Schizophrenia. Turkish Journal of Psychiatry 2016;27(3):170-175.