The effect of the content of ApoA-I in peripheral blood on the state of immune homeostasis in people living in extreme climatic conditions of the Arctic

Abstract

The paper presents data on the impacts of the content of ApoA-I in peripheral blood on the state of immune homeostasis in people living in extreme climatic conditions of the Arctic. From the village of Revda, Murmansk region, 191 people were examined, 160 women and 31 men, aged from 21 to 55 years. The analysis of the results was carried out depending on the level of ApoA-I content: 111 examined people had a low content of ApoA-I (< 115 mg/dl) and 80 people had a concentration of ApoA-I - within the physiological norm (115-220 mg/dl). Deficiency of ApoA-I is associated with an increase in plasma concentrations of total cholesterol in 37.5% and triglycerides in 62.5% of cases. Low content of ApoA-I is associated with a decrease in the content of neutrophilic granulocytes and an increase in the concentration of small lymphocytes, IL-10 and IgE. Deficiency of ApoA-I is associated with an increase in the content of CD45RA+, CD16+, CD56+ lymphocyte phenotypes in blood. Low concentrations of ApoA-I are associated with low expression activity of L-selectin gene and free L-selectin ligand. Due to deficiency of ApoA-I, no significant differences were detected in the content of transferrin, free transferrin receptor, haptoglobin, free calcium-dependent cell adhesion protein, and free pool of receptors involved in apoptosis. Conclusion: deficiency of ApoA-I in blood plasma is associated with increased migration of neutrophils into the tissue and cell-mediated cytotoxicity of lymphocytes and occurs because of the effect of decreased activity of the level of antioxidant defense, changes in the structure of cell membranes and the participation of adhesion molecules.