Affiliation:
1. N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of the Russian Federation; A.I. Evdokimov Moscow State University of Medicine and Dentistry Ministry of Health of the Russian Federation
2. Medical Institute of G.R. Derzhavin Tambov State University of the Ministry of Science and Higher Education of the Russian Federation
3. N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of the Russian Federation
4. Privolzhsky Research Medical University
5. A.I. Evdokimov Moscow State University of Medicine and Dentistry Ministry of Health of the Russian Federation
Abstract
Analysis of long-term treatment results of 101 primary gastric cancer patients at various stages of the tumor process followed during 1 - 41 months (median - 6,4 months) from the onset of specific treatment are presented depending on the levels of soluble forms (s) of PD-1 receptor and its ligand PD-L1 in blood plasma. Overall survival assessed by Kaplan-Meyer analysis and with the help of Cox multiparametric regression model was applied as the criterion of prognostic value. It was found that at high (≥ 35 pg/ml) sPD-L1 levels in blood plasma, the overall survival of patients with gastric cancer was statistically significantly lower than at the marker’s levels below 35 pg / ml (p <0.045): 1-year survival comprised 78 and 96%, 2-year - 52 and 78%; 3-year - 40 and 61% at high and low sPD-L1 respectively. Median survival of patients with high plasma sPD-L1 comprised 29 months, of those with low sPD-L1 was not achieved during the whole follow-up period. This trend was observed not only in the total group of stage I-IV gastric cancer patients, but also in patients at the early stages of the disease, though sPD-L1 did not show an independent prognostic value in multiparametric model. At the same time, the overall survival of patients with gastric cancer did not depend on the baseline levels sPD-1 in blood plasma. Thus, soluble ligand sPD-L1 can be considered as a potentially valuable factor for prognosis of gastric cancer patients’ survival, and, probably, of anti-PD-1/PD-L1 treatment efficiency, but further studies and patients’ monitoring are required to prove this statement.
Subject
Biochemistry (medical),Medical Laboratory Technology,General Medicine
Reference27 articles.
1. Kushlinskii N.E., Fridman M.V., Morozov A.A., Gershtein E.S., Kadagidze Z.G., Matveev V.B. Modern approaches to the immunotherapy of kidney cancer. Onkourologiya. 2018; 14 (2): 54-67. (in Russian)
2. Naberezhnov D.S., Morozov A.A., Fridman M.V., Alferov A.A., Bazaev V.V., Kushlinskii N.E. Система PD-1/PD-L1 system in the immunotherapy of kidney cancer Part 1. PD-1/PD-L1 signaling pathway, its role in immune system and immunotherapy. Meditsinskiy alfavit. 2018; 2(29): 22-31. (in Russian)
3. Kadagidze Z.G., Chertkova A.I., Zabotina T.N., Khulamkhanova M.M., Kushlinskii N.E. CTLA-4, PD-1/PD-L1 negative regulators of T-cell immunity in the therapy of ovarian cancer. Onkoginekologiya. 2019; 2(30): 4-15. (in Russian)
4. Hamanishi J., Konishi I. Targeting the PD-1/PD-L1 immune checkpoint signal – a new treatment strategy for cancer. Gan To Kagaku Ryoho. 2014; 41(9):1071–6.
5. Mahoney K.M., Freeman G.J., McDermott D.F. The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma. Clin. Ther. 2015; 37(4):764–82.
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献