Polyamines of biological fluids of the body and the diagnostic value of their determination in clinical and laboratory researches (review of literature)

Author:

Ploskonos M. V.1ORCID

Affiliation:

1. Astrakhan State Medical University Health Ministry of Russian Federation

Abstract

The review provides the analysis of the content of the main polyamines (PA) - spermine, spermidine and putrescine in the most important biological fluids of the human body (blood, urine, seminal fluid, etc.). The assessment of their diagnostic and prognostic value in clinical practice is carried out. The novelty and value of assessing of the level of PA metabolites as new diagnostic markers of various diseases has been shown. Among such diseases as cancer, stroke, renal failure, for which the search for early markers is especially relevant. This survey data can be of practical interest and taken into account in estimating the level of PA and its derivatives in clinical and laboratory reseaches. The literature search for the review was carried out using the Scopus, Web of Science, MedLine, RSCI databases.

Publisher

EKOlab

Subject

Biochemistry, medical,Medical Laboratory Technology,General Medicine

Reference60 articles.

1. Agostinelli E., Marques M.P., Calheiros R. Polyamines: fundamental characters in chemistry and biology. Amino Acids. 2010; 38:393-403.

2. Ploskonos M.V., Nikolaev A.A. Determination of polyamines in various biological media. Klinichescheskaya laboratornaya diagnostika. 2011; 3:16-9. (in Russian)

3. Silachev D.N., Plotnikov E.Yu., Goryunov K.V., Romanov A.Yu., Ploskonos M.V., Dolgushina N.V., Nikolaev A.A., Torov D.B., Sukhikh G.T. The role of polyamines in functioning of reproductive system cells. Tsitologiya. 2018; 60:3:164-72. https://doi.org/10.31116/tsitol.2018.03.02) (in Russian)

4. Kagramanova A.T., Tishchenko L.D. Berezov T.T. Ornithine decarboxylase activity of the epidermis in psoriasis as a biochemical indicator of the hyperproliferative process. Byulleten’ eksperimental’noy biologii I meditsiny. 1993; 6:618-20. (in Russian)

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