Prognostic significance of the TNM system criteria, levels of serum insulin-like growth factors and their transport proteins, VEGF and MMP-7 in colorectal cancer-Reference-Cited by-同舟云学术

Prognostic significance of the TNM system criteria, levels of serum insulin-like growth factors and their transport proteins, VEGF and MMP-7 in colorectal cancer

Published:2021-08-13 Issue:8 Volume:66 Page:459-464
ISSN:2412-1320
Container-title:Russian Clinical Laboratory Diagnostics
language:
Short-container-title:Klin. lab. diagn.

Author:

Nikolaev A. A.¹^ORCID,Babkina I. V.²^ORCID,Gershtein Elena Sergeevna¹^ORCID,Alferov A. A.¹^ORCID,Delektorskaya V. V.²^ORCID,Mamedli Z. Z.²^ORCID,Kushlinskii N. E.¹^ORCID

Affiliation:

1. N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of the Russian Federation; A.I. Evdokimov Moscow State University of Medicine and Dentistry Ministry of Health of the Russian Federation

2. N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of the Russian Federation

Abstract

The analysis of long-term results of treatment of 88 primary patients with colon adenocarcinoma at various stages of tumor process is presented, taking into account the TNM system criteria, and serum IGF-1, IGF-2, IGFBP-1, IGFBP-2, IGFBP-3, VEGF, and MMP-7 levels. The overall survival rate assessed by Kaplan-Meier method and Cox multivariate regression model was used as the criterion of prognosis. It was established that IGF-1, IGFBP-2 and VEGF serum levels along with the stage of colorectal cancer might be considered as statistically significant independent predictors of overall survival in patients.

Publisher

EKOlab

Subject

Biochemistry (medical),Medical Laboratory Technology,General Medicine

Reference22 articles.

1. Zaridze D.G., Kaprin A.D., Stilidi I.S. Dynamics of morbidity and mortality from malignant neoplasms in Russia. Voprosy onkologii. 2018; 64 (5): 578-90. (in Russian)

2. Moons L., Mariman A., Vermeir P., Colemont L., Clays E., Van Vlierberghe H., Vogelaers D. Sociodemographic factors and strategies in colorectal cancer screening: a narrative review and practical recommendations. Acta Clin. Belg. 2020; 75(1): 33-41.

3. Yakar S., Leroith D., Brodt P. The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: Lessons from animal models. Cytokine Growth Factor Rev. 2005; 16(4-5): 407-20.

4. Conn G., Soderman D.D., Schaeffer M.-T., Wile M., Hatcher V.B., Thomas K.A. Purification of a glicoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line. Proc. Natl. Acad. Sci. USA. 1990; 87(4): 1323-27.

5. van Beijnum J.R., Pieters W., Nowak-Sliwinska P., Griffioen A.W. Insulin-like growth factor axis targeting in cancer and tumour angiogenesis - the missing link. Biol. Rev. Camb. Philos. Soc. 2017; 92(3): 1755-68.