Diagnostic value of platelet parameters and megakaryocyte formula of bone marrow in idiopathic thrombocytopenic purpura

Author:

Gabrilchak A. I.1

Affiliation:

1. Samara State Medical University

Abstract

The parameters of the megakaryocyte formula and peripheral blood platelet indices were studied in 237 people with diagnoses of idiopathic thrombocytopenic purpura (ITP) and myelodysplastic syndrome (MDS). A correlation analysis was performed between megakaryocyte subpopulations and platelet counts. The threshold values for MPV, PCT and PDW were determined by ROC analysis with the construction of the ROC curve, the calculation of the area under the curve (AUC) and the cutoff threshold. The obtained values make it possible to make a differential diagnosis between ITP and MDS by platelet parameters of peripheral blood without examining the bone marrow.

Publisher

EKOlab

Subject

Biochemistry (medical),Medical Laboratory Technology,General Medicine

Reference15 articles.

1. Melikyan A.L., Pustovaya E.I., Tsvetaeva N.V., Ptushkin V.V., Gritsaev S.V., Golenkov A.K. et al. National clinical recommendations for the diagnosis and therapy of idiopathic thrombocytopenic purpura (primary immune thrombocytopenia) in adults (2016). Gematologiya I tranafuziologiya. 2017; 62(1, suppl.1): 1-60. (in Russian)

2. Kovaleva L.G., Pustovaya E.I., Safonova T.I. Idiopathic Trombocytopenic Purpura (ITP) in adults. Primary immune thrombocytopenia (ITP) in adults. Verlgof’s Disease. Moscow: Nye Mun; 2014. (in Russian)

3. Liebman H.A., Pullarkat V. Diagnosis and management of immune thrombocytopenia in the era of thrombopoietin mimetics. Hematology Am. Soc. Hematol. Educ. Program. 2011; 384–90.

4. Savchenko V.G., Parovichnikova E.N., Kokhno A.V., Semochkin S.V., Afanas’ev B.V., Morozova E.V. et al. National clinical recommendations for the diagnosis and treatment of myelodysplastic syndromes adults. Gematologiya I transfuziologiya. 2016; 61 (1S) (4): 1-32. (in Russian)

5. Italiano J.E., Shivdasani R.A. Megakaryocytes and beyond: the birth of platelets. J. Thromb. Haemost. 2003; 1:1174–82.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3