Pseudomonas aeruginosa efflux pump superfamily (review of literature)

Author:

Ivanov Mikhail Eduardovich1ORCID,Fursova N. K.1ORCID,Potapov V. D.1ORCID

Affiliation:

1. Federal Budget Institution of Science «State Research Center for Applied Microbiology & Biotechnology»

Abstract

The significant increase in the number of antibiotic-resistant microorganisms observed in recent years is a public health problem worldwide. One of the molecular mechanisms for the formation of antimicrobial resistance in bacteria is the presence of efflux pumps. The review presents an analysis of experimental studies related to the study of efflux pumps in clinical strains of Pseudomonas aeruginosa, one of the representatives of hospital pathogens of the ESKAPE group. This review is intended for specialists developing new types of drugs against antibiotic-resistant strains, as well as researchers studying the mechanisms of bacterial resistance to antibiotics, heavy metals, biocides and other antimicrobial factors.

Publisher

EKOlab

Subject

Biochemistry (medical),Medical Laboratory Technology,General Medicine

Reference57 articles.

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3. Preventing the COVID-19 pandemic from causing an antibiotic resistance catastrophe [Electronic resource]. World Health Organization: https://www.euro.who.int/ru/health-topics/disease-prevention/antimicrobial-resistance/news/news/2020/11/preventing-the-covid-19-pandemic-from-causing-an-antibiotic-resistance-catastrophe (access date: 10.08.2021).

4. Alonso B., Fernández-Barat L., Di Domenico E.G., Marín M., Cercenado E., Merino I. et al. Characterization of the virulence of Pseudomonas aeruginosa strains causing ventilator-associated pneumonia. BMC Infect. 2020; 20(1): 909. https://doi.org/10.1186/s12879-020-05534-1

5. What is Pseudomonas aeruginosa? [Electronic resource]. EHA Consulting Group: Public Health Consulting, Epidemiology, & Food Safety Consultants. https://www.ehagroup.com/resources/pathogens/pseudomonas-aeruginosa (access date 26.04.2021).

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