Role of HLA genes in development of HLA-alloimmunization in blood recipients-Reference-Cited by-同舟云学术

Role of HLA genes in development of HLA-alloimmunization in blood recipients

Published:2022-05-21 Issue:5 Volume:67 Page:292-295
ISSN:2412-1320
Container-title:Russian Clinical Laboratory Diagnostics
language:
Short-container-title:Klin. lab. diagn.

Author:

Butina E. V.¹^ORCID,Sherstnev F. S.¹^ORCID,Maksimov O. D.¹^ORCID,Yovdiy A. V.¹^ORCID,Paramonov I. V.¹^ORCID

Affiliation:

1. Federal State Budget Institution of Science «Kirov Scientific Research Institute of Hematology and Blood Transfusion of the Federal Medical-Biological Agency»

Abstract

A genetically determined predisposition to the development of HLA-alloimmunization as a result of blood transfusions is associated with the presence of HLA-alleles DRB1*04, DQA1*03:01, DQA1*05:01 and HLA-haplotype DRB1*04-DQA1*03:01-DQB1*03:02 in the genotypes of recipients. The risk of antibody production is reduced in patients with HLA-alleles DRB1*16, DQA1*01:02, DQB1*05:02 and HLA-haplotype DRB1*16-DQA1*01:02-DQB1*05:02.

Publisher

EKOlab

Subject

Biochemistry (medical),Medical Laboratory Technology,General Medicine

Reference11 articles.

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