Presence and quantity of antibodies after vaccination «Gam-COVID-Vac»

Abstract

The determine is to study the presence and quantity of specific antibodies in individuals vaccinated against COVID-19. A study of 37 blood serums of healthy adults vaccinated against COVID-19 with the vaccine «Gam-COVID-Vac» (or «Sputnik V», National Research Center of Epidemiology and Microbiology named after N.F. Gamalei) was conducted. Blood sampling was carried out 42 days after the introduction of the first component of the vaccine, and 3, 4, 5, 6 months after the end of the full course of vaccination. The presence and quantity of total IgM/IgG antibodies in the blood serum was determined by immunochemiluminescence analysis on an automatic immunochemical analyzer «Cobas e 411» («Roche Diagnostics», Germany). The results were processed by modern statistical methods. 42 days after the introduction of the first component of the vaccine «Gam-COVID-Vac» AT was developed in all study participants, the values of their number were variable and ranged from 36,43 to 265,43 BAU/ ml. 3, 4, 5 and 6 months after the end of the full course of vaccination AT were detected in all study participants. 6 months after the end of the full course of vaccination the number antibodies decreased by 28,16%.