Affiliation:
1. National Research Tomsk State University
2. Siberian State Medical University
3. South Ural State Medical University
4. National Research Tomsk State University; National Research Tomsk Polytechnic University
Abstract
Bone tissue is a physiogenic organomineral aggregate consisting of organic (collagen, fats, sugars) and mineral (hydroxlyapatite) components. Osteoporosis is one of the most common bone diseases leading to disruption of bone tissue mineralization processes. To study the dynamics of changes in
hydroxylapatite during osteoporosis, an experiment was conducted on laboratory animals with the simulation of systemic osteoporosis using ovariectomy (the surgical removal of an ovary or ovaries). The chemical composition of the mineral component of bone tissue was studied using electron microprobe analysis with further statistical processing of the results. The osteoporosis of bone tissue results in an increase in the content of isomorphic Mg, Al, and K in hydroxylapatite. A signifcant role of Al in the development of the disease was established using multivariate statistics methods. The X-ray diffraction revealed the increase in the unit cell parameters of hydroxylapatite with the osteoporosis progression. The results of IR spectroscopy showed the presence of a carbonate group in hydroxylapatite, the content of which decreases with disease.
Publisher
South Urals Federal Research Center for Mineralogy and Geoecology of the Urals Branch of the RAS
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