Coexpression network analysis identified lncRNAs-mRNAs with potential relevance in African ancestry prostate cancer-Reference-Cited by-同舟云学术

Coexpression network analysis identified lncRNAs-mRNAs with potential relevance in African ancestry prostate cancer

Published:2021-10 Issue:9 Volume:7 Page:
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Parra-Medina Rafael¹²³^ORCID,López-Kleine Liliana⁴^ORCID,Ramírez-Clavijo Sandra¹^ORCID,Payán-Gómez César¹^ORCID

Affiliation:

1. Faculty of Natural Sciences, Universidad del Rosario, Bogotá, Colombia

2. Department of Pathology, Research Institute, Fundación Univeristaria de Ciencias de la Salud, Bogotá, Colombia

3. Deparment of Pathology, Instituto Nacional de Cancerología, Bogotá, Colombia

4. Department of Statistics, Faculty of Science, Universidad Nacional de Colombia, Bogotá, Colombia

Abstract

Aim: This study aims to investigate similarities and differences using lncRNA and mRNA coexpression network analysis in African ancestry (AA) and European ancestry (EA) among prostate cancer (PCa) patients. Methods: We performed weighted gene coexpression network analysis of the expression from 49 of AA and 49 of EA to identify lncRNAs-mRNAs. Results: 27 lncRNAs and 36 mRNAs were highly expressed in patients of AA. Two mRNAs and their antisense lncRNAs were expressed. Additionally, seven mRNAs were DE or coexpressed and had an impact on survival. Conclusion: We present a list of lncRNAs and mRNAs that were DE and coexpressed when comparing patients of AA and EA, and these data are a resource for future studies to understand the role of lncRNAs.

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.2144/fsoa-2021-0076