Ct,IL-18polymorphism, and laboratory biomarkers for predicting chemosensory dysfunctions and mortality in COVID-19

Author:

Smail Shukur Wasman1ORCID,Babaei Esmaeil23ORCID,Amin Kawa4ORCID

Affiliation:

1. Department of Biology, College of Science, Salahaddin University-Erbil, Iraq

2. Department of Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran

3. Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq

4. College of Medicine, University of Sulaimani, Sulaymaniyah, Iraq

Abstract

Aim: Patients with COVID-19 often experience chemosensory dysfunction. This research intends to uncover the association of RT-PCR Ct value with chemosensory dysfunctions and SpO2. This study also aims to investigate Ct, SpO2, CRP, D-dimer, and -607 IL-18 T/G polymorphism in order to find out predictors of chemosensory dysfunctions and mortality. Materials & methods: This study included 120 COVID-19 patients, of which 54 were mild, 40 were severe and 26 were critical. CRP, D-dimer, RT-PCR, and IL-18 polymorphism were evaluated. Results & conclusion: Low Ct was associated with SpO2dropping and chemosensory dysfunctions. IL-18 T/G polymorphism did not show an association with COVID-19 mortality; conversely, age, BMI, D-dimer and Ct values did.

Publisher

Future Science Ltd

Subject

Biotechnology

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