State of the art in epitope mapping and opportunities in COVID-19-Reference-Cited by-同舟云学术

State of the art in epitope mapping and opportunities in COVID-19

Published:2023-01 Issue:1 Volume:9 Page:
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Hamed Samira M¹^ORCID,Sakr Masarra M²^ORCID,El-Housseiny Ghadir S²^ORCID,Wasfi Reham¹^ORCID,Aboshanab Khaled M²^ORCID

Affiliation:

1. Department of Microbiology & Immunology, Faculty of Pharmacy, October University for Modern Sciences & Arts (MSA), Giza, 12451, Egypt

2. Department of Microbiology & Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt

Abstract

The understanding of any disease calls for studying specific biological structures called epitopes. One important tool recently drawing attention and proving efficiency in both diagnosis and vaccine development is epitope mapping. Several techniques have been developed with the urge to provide precise epitope mapping for use in designing sensitive diagnostic tools and developing rpitope-based vaccines (EBVs) as well as therapeutics. In this review, we will discuss the state of the art in epitope mapping with a special emphasis on accomplishments and opportunities in combating COVID-19. These comprise SARS-CoV-2 variant analysis versus the currently available immune-based diagnostic tools and vaccines, immunological profile-based patient stratification, and finally, exploring novel epitope targets for potential prophylactic, therapeutic or diagnostic agents for COVID-19.

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.2144/fsoa-2022-0048

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