Identification of shared fatty acid metabolism related signatures in dilated cardiomyopathy and myocardial infarction-Reference-Cited by-同舟云学术

Identification of shared fatty acid metabolism related signatures in dilated cardiomyopathy and myocardial infarction

Published:2023-03 Issue:3 Volume:9 Page:
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Huang Baoyi¹^ORCID,Lin Hanying²,Zhang Qingfang³,Luo Yujun⁴,Zhou Biyao⁵,Zhuo Zewei³,Sha Weihong³,Wei Jiahui¹,Luo Lihua¹,Zhang Huajuan³,Chen Kequan⁶

Affiliation:

1. Guangzhou Medical University, Guangzhou, 511436, China

2. Department of Endocrinology, The First People’s Hospital of Zhaoqing, Zhaoqing, 526020, China

3. Department of Gastroenterology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China

4. Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China

5. Department of Periodontics, Stomatological Hospital, Southern Medical University, Guangzhou, 510280, China

6. Department of Gastroenterology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China

Abstract

Aim: It is to be elucidated the risk-predictive role of differentially expressed fatty acid metabolism related genes (DE-FRGs) in dilated cardiomyopathy (DCM) and myocardial infarction. Materials & methods: Four gene enrichment analyses defined DE-FRGs’ biological functions and pathways. Three strategies were applied to identify risk biomarkers and construct a nomogram. The 4-DE-FRG correlation with immune cell infiltration, drugs, and ceRNA was explored. Results: DE-FRGs were enriched in lipid metabolism. A risk nomogram was established by ACSL1, ALDH2, CYP27A1 and PPARA, demonstrating a good ability for DCM and myocardial infarction prediction. PPARA was positively correlated with adaptive immunocytes. Thirty-five drugs are candidate therapeutic targets. Conclusion: A nomogram and new biological targets for early diagnosis and treatment of DCM and myocardial infarction were provided.

Funder

The Natural Science Foundation for Distinguished Young Scholars of Guangdong Province

Guangdong Science and Technology Innovation Strategy Special Funds

Project to Attract Foreign Experts from Minister of Science and Technology of China

The Climbing Program of Introduced Talents and High-level Hospital Construction Project of Provincial People's Hospital

National-level university students Innovative Training Program

Jointly funded by Guangzhou Municipal Bureau of Science and Technology for “Dengfeng Hospital” project

Science and Technology Innovation Project for college students of Guangzhou Medical University

Natural Science Foundation of Guangdong Province

Famous overseas teachers from Science and Technology Department of Province

The National Natural Science Foundation of China

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.2144/fsoa-2023-0008

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