Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study-Reference-Cited by-同舟云学术

Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study

Published:2022-06 Issue:5 Volume:8 Page:
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Vaz Salgado María Angeles¹^ORCID,Earl Julie¹^ORCID,Berrocal Victor Rodriguez²,Arrieta Freddy Salge²,Gomez Ana¹,Sepulveda-Sanchez Juan Manuel³^ORCID,Perez-Nuñez Ángel⁴^ORCID,de la Fuente Elena Corral¹,Lourido Daniel⁵^ORCID,MaríaVillamayor ¹,Pian Hector⁶,Muriel Alfonso⁷^ORCID,Rossi Elisabetta⁸⁹^ORCID,Zamarchi Rita⁹^ORCID,Carrato Alfredo¹^ORCID,Ley Luis²^ORCID

Affiliation:

1. Medical Oncology Department. Ramón y Cajal Hospital. IRYCIS, CIBERONC, Madrid, 28034, Spain

2. Neurosurgery Department. Ramón y Cajal Hospital, Madrid, 28034, Spain

3. Medical Oncology Department. 12 de Octubre Hospital. Instituto de Investigación I+12, Madrid, 28041, Spain

4. Neurosurgery Department. 12 de Octubre Hospital, Madrid, 28034, Spain

5. Radiology Department. Ramón y Cajal Hospital, Madrid, 28034, Spain

6. Pathology Department, Ramón y Cajal Hospital, Madrid, 28034, Spain

7. Clinical Biostatistic Unit, Hospital Universitario Ramón y Cajal, IRYCIS, CIBERESP, Nursing Department Universidad de Alcalá Madrid, 28034, Spain

8. Department of Surgery, Oncology & Gastroenterology, University of Padova, Padua, 35124, Italy

9. Veneto Institute of Oncology IOV – IRCCS, Padua, 35128, Italy

Abstract

Aim: Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis. Materials & methods: A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, using the US FDA-approved CellSearch system. Results: A CEC cutoff value was estimated using a receiver operating curve (ROC) and patients were classified into two groups: <40 CEC/4 ml and >40 CEC/4 ml blood. Median overall survival was 25.33 months for group 1 and 8.23 months for group 2 cases (p = 0.02). There was no correlation between CEC and PWI (perfusion-weighted imaging) RM. Conclusion: CEC detection has a prognostic value in GB cases at diagnosis.

Funder

Grupo Español de Investigación en Neurooncologia

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.2144/fsoa-2022-0008

Reference30 articles.

1. Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

2. Mechanisms of angiogenesis in gliomas

3. Microvessel density is a prognostic indicator for patients with astroglial brain tumors

4. Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Synopsis of Biomarkers in Glioblastoma: Past and Present;Current Issues in Molecular Biology;2024-07-03

2. Circulating endothelial cells in pathophysiology;Current Opinion in Hematology;2024-02-15

3. Tumor-Derived Biomarkers in Liquid Biopsy of Glioblastoma;World Neurosurgery;2023-02