Combination of urinary fibrinogen β-chain and tyrosine-phosphorylated proteins for the detection of bladder cancer-Reference-Cited by-同舟云学术

Combination of urinary fibrinogen β-chain and tyrosine-phosphorylated proteins for the detection of bladder cancer

Published:2021-10 Issue:9 Volume:7 Page:
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Giribaldi Giuliana¹^ORCID,Filippini Claudia²,Viberti Clara³,Khadjavi Amina¹,Finesso Nicole¹,Ulliers Daniela¹,Turini Stefano⁴,Bressan Bruno Emilio¹,Pecoraro Francesca¹,Prato Mauro⁴,Allione Alessandra³,Bellis Matteo De⁵,Montefusco Gabriele⁵,Bonomessi Giulia⁵,Allasia Marco⁵,Matullo Giuseppe³⁶,Soria Francesco⁵,Gontero Paolo⁵

Affiliation:

1. Department of Oncology, University of Turin, Turin, Italy

2. Department of Surgical Sciences, University of Turin, Turin, Italy

3. Department of Medical Sciences, University of Turin, Turin, Italy

4. Department of Neurosciences, University of Turin, Turin, Italy

5. Division of Urology, Department of Surgical Sciences, AOU Città della Salute e della Scienza, Torino School of Medicine, Turin, Italy

6. SC Medical Genetics, AOU Città della Salute e della Scienza, Turin, Italy

Abstract

Aim: to evaluate the performance of urinary fibrinogen β-chain (FBC) – either alone or associated with urinary tyrosine-phosphorylated proteins (UPY) – as bladder cancer (BCa) diagnostic biomarker. Materials & methods: 164 subjects were tested. Results: significantly different FBC and UPY levels were found between BCa patients and controls, as well as between low-grade and high-grade cancers. The diagnostic accuracy was 0.84 for FBC and 0.87 for UPY. The combination of FBC and UPY improved the accuracy to 0.91. The addition of clinical variables (age, gender, and smoking habit) to FBC and UPY into a model for BCa prediction significantly improved the accuracy to 0.99. The combination of FBC and UPY adjusted for clinical variables associates with the highest sensitivity and good specificity. Conclusion: urinary FBC and UPY could be used as biomarkers for BCa diagnosis.

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.2144/fsoa-2021-0060