Curcumin micelles entrapped in eudragit S-100 matrix: a synergistic strategy for enhanced oral delivery

Author:

Yusuf Helmy1ORCID,Rahmawati Rizka Arifa1,Syamsur Rijal M Agus1,Isadiartuti Dewi1

Affiliation:

1. Department of Pharmaceutics, Faculty of Pharmacy, Universitas Airlangga, Jl Mulyorejo Surabaya 60115, Indonesia

Abstract

Background: Therapeutic activities of curcumin (CUR) via oral administration are hampered by the lack of bioavailability due to its poor water solubility and rapid degradation in GI tract. Materials & methods: This preliminary study developed CUR micelle-eudragit S100 (EUD) dry powder (CM-EDP) spray-dried formulations. Poloxamer 407 was used as a micelle-forming agent and EUD as an entrapping matrix for protection over hydrolysis and enzymes in the GI tract. Results: The morphology of CM-EDP showed agglomeration with cratering on the surface of particles. Differential thermal analysis and x-ray diffractometry data exhibited evidence that CUR was converted into amorphous solid. An increased concentration of micelle-forming and dispersion matrix polymers resulted in a high fraction of drug being converted into the amorphous state. A significant increase in dissolution by 7–10 times was achieved compared with that of raw CUR. Conclusion: The present study disclosed the CM-EDP potency for future development of CUR oral formulation.

Funder

The Directorate General of Higher Education, The Republic of Indonesia

Publisher

Future Science Ltd

Subject

Biotechnology

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