MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis-Reference-Cited by-同舟云学术

MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis

Published:2021-06 Issue:5 Volume:7 Page:
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Kiyoshima Chihiro¹^ORCID,Shirasu Naoto²³,Urushiyama Daichi¹,Fukagawa Satoshi¹,Hirakawa Toyofumi¹,Yoshikawa Kenichi¹,Izuchi Daisuke¹,Miyata Kohei¹,Kurakazu Masamitsu¹,Yotsumoto Fusanori¹^ORCID,Hiromatsu Kenji⁴,Nomiyama Makoto⁵,Eiji Ohta⁶,Hirose Shinichi⁷,Ogura Yoshitoshi⁸,Hayashi Tetsuya⁸,Hata Kenichiro⁹,Nabeshima Kazuki¹⁰,Yasunaga Shin'ichiro²³,Miyamoto Shingo¹^ORCID

Affiliation:

1. Department of Obstetrics & Gynecology, Fukuoka University, Fukuoka, Japan

2. Department of Biochemistry, Fukuoka University, Fukuoka, Japan

3. Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka, Japan

4. Department of Microbiology & Immunology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

5. Department of Obstetrics & Gynecology, National Hospital Organization Saga National Hospital, Saga, Japan

6. Center for Maternal, Foetal & Neonatal Medicine, Fukuoka University Hospital, Fukuoka, Japan

7. Departemnt of Pediatrics, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

8. Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan

9. Department of Maternal-Fetal Biology, National Research Institute for Child Health & Development, Tokyo, Japan

10. Department of Pathology, Fukuoka University School of Medicine & Hospital, Fukuoka, Japan

Abstract

Background: This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis. Materials & methods: Amniotic fluid samples from 37 patients with severe chorioamnionitis were subjected to miRNA array analysis and ddPCR™. Diagnostic values were assessed using the receiver operating characteristic curve. The patients were separated into three groups according to Blanc’s criteria. Results: The expression of miR-4535 and miR-1915-5p was significantly correlated with the copy number of 16S rDNA, had extremely high diagnostic accuracy for severe chorioamnionitis, and was linked to maternal and fetal inflammation. Conclusion: miR-4535 and miR-1915-5p serve as promising biomarkers for the diagnosis of severe chorioamnionitis.

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.2144/fsoa-2021-0006

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