Hyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage-Reference-Cited by-同舟云学术

Hyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage

Published:2022-04 Issue:4 Volume:8 Page:
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Mello Tanira Giara¹²³,Rosado-de-Castro Paulo Henrique³⁴⁵^ORCID,Vasques Juliana Ferreira¹³⁵^ORCID,Pinhão Carolina¹^ORCID,Santos Tayná Monteiro¹^ORCID,de Lima Renata Rodrigues¹,Foerster Bernd Uwe⁶,Paiva Fernando Fernandes⁶,Mendez-Otero Rosalia¹³^ORCID,Pimentel-Coelho Pedro Moreno¹³^ORCID

Affiliation:

1. Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil

2. Instituto de Engenharia Nuclear, Comissão Nacional de Energia Nuclear, Rio de Janeiro, RJ, 21941-614, Brazil

3. Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa, Rio de Janeiro, RJ, 21941-902, Brazil

4. Departamento de Radiologia, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil

5. Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil

6. Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, SP, 13566-590, Brazil

Abstract

Aim: Intracerebral hemorrhage (ICH) has limited therapeutic options. We have shown that an intravenous injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSC) 24 h after an ICH in rats reduced the residual hematoma volume after a moderate hemorrhage but was inefficient in severe ICH. Here, we investigated whether a treatment in the hyperacute phase would be more effective in severe ICH. Materials & methods: Wistar rats were randomly selected to receive an intravenous injection of hUC-MSC or the vehicle 1 h after a severe ICH. Results: The hyperacute treatment with hUC-MSC did not affect the 22-day survival rate, the motor function or the residual hematoma volume. Conclusion: These results indicate the need for optimization of hUC-MSC-based therapies for severe ICH.

Funder

Departamento de Ciência e Tecnologia (DECIT) do Ministério da Saúde and the Conselho Nacional de Desenvolvimento Científico e Tecnológico

Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superio

Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.2144/fsoa-2021-0121

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