Investigation of Copaifera genus as a new source of antimycobaterial agents

Author:

Alves Jéssica Aparecida1ORCID,Abrão Fariza1ORCID,Silva Moraes Thaís da1ORCID,Damasceno Jaqueline Lopes1ORCID,dos Santos Moraes Marcos Fernando2ORCID,Sola Veneziani Rodrigo Cassio2ORCID,Ambrósio Sérgio Ricardo2ORCID,Bastos Jairo Kenupp3ORCID,Dantas Miranda Mayker Lázaro4ORCID,Gomes Martins Carlos Henrique15ORCID

Affiliation:

1. Research Laboratory of Applied Microbiology, University of Franca, Franca, SP, Brazil

2. Nucleus of Research in Sciences & Technology, University de Franca, Franca, SP, Brazil

3. School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil

4. Federal Institute of Education, Science & Technology of the Triângulo Mineiro, Uberlândia, MG, Brazil

5. Laboratory of Research on Antimicrobial Trials (LaPEA), Institute of Biomedical Sciences – ICBIM, Federal University of Uberlândia, Uberlândia, MG, Brazil

Abstract

Aim: This paper reports on the antimycobacterial activity of the oleoresins and extracts obtained from Copaifera spp. Materials & methods: The minimum inhibitory concentration (MIC) and fractional inhibitory concentration index techniques helped to evaluate the effect of these oleoresins and extracts against six strains of mycobacteria that cause tuberculosis. Results & conclusion: Among the assayed oleoresins and plant extracts, the Copaifera langsdorffii, Copaifera duckei, Copaifera reticulata and Copaifera trapezifolia oleoresins provided the lowest MIC values against some of the tested strains. The combination of Copaifera spp. samples with isoniazid did not evidence any synergistic action. Some Copaifera spp. oleoresins may represent a future source for the discovery of new antimycobacterial drugs due to their low MIC values.

Publisher

Future Science Ltd

Subject

Biotechnology

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