The viral capsid as novel nanomaterials for drug delivery

Author:

Aljabali Alaa AA1ORCID,Hassan Sk Sarif2,Pabari Ritesh M3,Shahcheraghi Seyed H4,Mishra Vijay5ORCID,Charbe Nitin B6,Chellappan Dinesh K7,Dureja Harish8ORCID,Gupta Gaurav9ORCID,Almutary Abdulmajeed G10,Alnuqaydan Abdullah M10,Verma Suresh K11,Panda Pritam K11,Mishra Yogendra Kumar12,Serrano-Aroca Ángel13,Dua Kamal14ORCID,Uversky Vladimir N15,Redwan Elrashdy M16,Bahar Bojlul17,Bhatia Amit18,Negi Poonam19,Goyal Rohit19,McCarron Paul20,Bakshi Hamid A20,Tambuwala Murtaza M20ORCID

Affiliation:

1. Faculty of Pharmacy, Department of Pharmaceutics & Pharmaceutical Technology, Yarmouk University, Irbid, 21163, Jordan

2. Department of Mathematics, Pingla Thana Mahavidyalaya, Paschim Medinipur, India

3. School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland

4. Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

5. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India

6. Department of Pharmaceutical Sciences, Rangel College of Pharmacy, Texas A&M University, Kingsville, TX 78363, USA

7. Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, 57000, Malaysia

8. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India

9. School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, 302017, India

10. Department of Medical Biotechnology, College of Applied Medical Sciences, Qassim University, Saudi Arabia

11. Condensed Matter Theory Group, Materials Theory Division, Department of Physics & Astronomy, Uppsala University, Uppsala, 75120, Sweden

12. University of Southern Denmark, Mads Clausen Institute, NanoSYD, Alsion 2, Sønderborg 6400, Denmark

13. Biomaterials & Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, Valencia, 46001, Spain

14. Discipline of Pharmacy, Graduate School of Health, University of Technology, Sydney, Australia

15. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA

16. King Abdulazizi University, Faculty of Science, Department of Biological Science, Saudi Arabia

17. International Institute of Nutritional Sciences & Food Safety Studies, School of Sport & Health Sciences, University of Central Lancashire, Preston, Lancashire, PR1 2HE, UK

18. Maharaja Ranjit Singh Punjab Technical University Dabwali Road, Bathinda, Punjab, 151001, India

19. School of Pharmaceutical Sciences, Shoolini University of Biotechnology & Management Sciences, Solan, 173229, India

20. School of Pharmacy & Pharmaceutical Science, Ulster University, Coleraine, County Londonderry, Northern Ireland, BT52 1SA, UK

Abstract

The purpose of this review is to highlight recent scientific developments and provide an overview of virus self-assembly and viral particle dynamics. Viruses are organized supramolecular structures with distinct yet related features and functions. Plant viruses are extensively used in biotechnology, and virus-like particulate matter is generated by genetic modification. Both provide a material-based means for selective distribution and delivery of drug molecules. Through surface engineering of their capsids, virus-derived nanomaterials facilitate various potential applications for selective drug delivery. Viruses have significant implications in chemotherapy, gene transfer, vaccine production, immunotherapy and molecular imaging.

Publisher

Future Science Ltd

Subject

Biotechnology

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