PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells-Reference-Cited by-同舟云学术

PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells

Published:2020-06-01 Issue:5 Volume:6 Page:
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Dietel Eric¹^ORCID,Brobeil Alexander²,Tag Claudia¹,Gattenloehner Stefan²,Wimmer Monika¹³

Affiliation:

1. Institute of Anatomy & Cell Biology, Justus-Liebig-University, Giessen 35392, Germany

2. Institute of Pathology, Justus-Liebig-University, Giessen 35392, Germany

3. Institute of Anatomy, Johannes-Kepler-University Linz, Linz 4040, Austria

Abstract

Aim: PTPIP51 interacts with NFκB signaling at the RelA and IκB level. NFκB signaling is linked to the initiation, progression and metastasis of breast cancer. Her2-amplified breast cancer cells frequently display activation of the NFκB signaling. We aimed to clarify the effects of NFκB inhibition on the NFκB- and MAPK-related interactome of PTPIP51 and cell viability in HaCat cells and SKBR3 cells. Results: IKK-16 selectively reduced cell viability in SKBR3 cells. PDTC induced a formation of the Raf1/14-3-3/PTPIP51 complex in SKBR3 cells, indicating a shift of PTPIP51 into MAPK signaling. Conclusion: IKK-16 selectively inhibits cell viability of SKBR3 cells. In addition, PTPIP51 might serve as the mediator between NFκB signaling and the MAPK pathway in SKBR3.

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.2144/fsoa-2019-0136

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