Correlation Between Incidences of Preterm Premature Rupture of Membrane with Leukocyturia and Bacteriuria at Wangaya General Hospital

Abstract

Prematurity or preterm birth can lead to perinatal and neonatal deaths. The leading cause of preterm labor is premature rupture of membranes. Infections are one of the leading causes of premature rupture of membranes, including urinary tract infections. This study aims to evaluate the correlation between bacteriuria and leukocyturia and the incidence of preterm premature rupture of membrane at Wangaya General Hospital Denpasar. This cross-sectional study used the target population of pregnant women undergoing treatment at Wangaya General Hospital. Sampling was carried out using the purposive sampling method. A total of 112 samples were enrolled in this study. Data was taken from the patient’s medical record from January 1, 2023, to December 31, 2023 and then analyzed. Based on the results, the mean age is 27.43 ± 5.95 years. The bivariate analysis showed significant results with an OR of 2.485; CI 95% 1.120–5.510; p = 0.024 for bacteriuria and OR 4.697; CI 95% 1.903–11.595; p < 0.001 for leukocyturia. Furthermore, the multivariate analysis obtained significant results for the leukocyturia variable with an adjusted OR value of 4.697; CI 95% 1.903–11.595; p = 0.001. Therefore, it can be concluded that positive bacteriuria and leukocyturia increase the risk of pregnant patients experiencing preterm PROM.