Author:
Dhingra A. K.,Chopra B.,Dass R,Mittal S. K.,
Abstract
Major depression is a debilitating disorder, predicted to be the second most prevalent human malady by the year 2020. Although a variety of chemical antidepressant remedies like tricyclic antidepressants, monoamine oxidase inhibitors and selective serotonin reuptake inhibitors are available, yet approximately 30% of depressed patients are resistant to the existing drugs and remaining 70% do not achieve full remission. Therefore, a constant urge continues for discovery of newer, better-tolerated and more efficacious treatments of depression, which include search for discovery of medicinal plants with potential antidepressant activity. The present paper discusses anti-depression potential of 70 medicinal plants with emphasis on their pre-clinical and clinical reports. Majority of plants shows antidepressant activity through serotonergic, noradrenergic and dopaminergic systems.
Publisher
Indian Drug Manufacturers' Association (IDMA)
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology
Reference98 articles.
1. 1. Rosenzweig-Lipson S, Beyer CE, Hughes ZA, Khawaja X, Rajarao SJ, et al, Differentiating antidepressants of the future: efficacy and safety, Pharmacol Ther, 2007, 113(1), 134–153.
2. 2. Dhingra D and Goyal PK, Inhibition of MAO and GABA: Probable mechanisms for antidepressant like activity of Nardostachys jatamansi in mice, Indian J Exp Biol, 2008, 46(4), 212-218.
3. 3. Schulz V, Safety of St. John’s Wort extract compared to synthetic antidepressants, Phytomed, 2006, 13(3), 199-204.
4. 4. Dhingra D and Sharma A, A review on antidepressant plants, Nat Prod Rad, 2006, 5(2), 144-152.
5. 5. Kessler RC, Epidemiology of women and depression, J Affect Disord, 2003, 74(1), 5-13.
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