IN-SILICO PRELIMINARY DOCKING SCREENING OF SOME ANTI-ALZHEIMER DRUGS

Abstract

Alzheimer’s disease is an irreversible, progressive brain disease that slowly destroys cognition function. It is neurodegenerative disease & most common kind of dementia. The main purpose of this work is to perform preliminary docking screening & estimate toxic properties of some anti-Alzheimer's drugs through computational software. To assess toxic properties of some anti-Alzheimer’s drugs, through Lipinski rule of five. Drug-likeness and toxic properties of selective drugs were determined by employing Osiris server. To calculate the biological activity spectrum through prediction of activity spectra for a drug which provide intrinsic property that correspond to different pharmacological effects, physiological and biochemical mechanisms of action. The OSIRIS toxicity predictions resulted for toxicity, cLogP value, drug likeness and drug-score of each molecular imprint. These findings are relevant for the exploration of drug action of any compound of Anti- Alzheimer’s drug using both animal models and in silico strategies.