Author:
Sharma S,Daniel K,Daniel V.,Sharma L,
Abstract
Alzheimer’s disease is an irreversible, progressive brain disease that slowly destroys cognition function. It is neurodegenerative disease & most common kind of dementia. The main purpose of this work is to perform preliminary docking screening & estimate toxic properties of some anti-Alzheimer's drugs through computational software. To assess toxic properties of some anti-Alzheimer’s drugs, through Lipinski rule of five. Drug-likeness and toxic properties of selective drugs were determined by employing Osiris server. To calculate the biological activity spectrum through prediction of activity spectra for a drug which provide intrinsic property that correspond to different pharmacological effects, physiological and biochemical mechanisms of action. The OSIRIS toxicity predictions resulted for toxicity, cLogP value, drug likeness and drug-score of each molecular imprint. These findings are relevant for the exploration of drug action of any compound of Anti- Alzheimer’s drug using both animal models and in silico strategies.
Publisher
Indian Drug Manufacturers' Association (IDMA)
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology
Reference20 articles.
1. Perry E. K., Tomlinson B. E., Blessed G., Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia, Brif. Med. J., 1978, 2(6150),1457–1459.
2. 2. Lipton S.A, Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation, Curr. Drug Targets, 2007, 8(5), 621-632.
3. 3. Ingole Shubhada R, Rajput Satyendra K, Sharma S.S, Cognition Enhancers: Current Strategies and Future Perspectives , CRIPS. 2008, 9(3), 42-48
4. 4. Pron, Cons, Alzheimer’s Disease: The Pros and Cons of Pharmaceutical, Nutritional, Botanical Stimulatory Therapies, with a Discussion of Treatment Strategies from the Perspective of Patients and Practitioners, AMR, 2005,15(3), 223-244.
5. 5. Olapeju G.A, Hans W.E, Shaker A.M. : Current therapies and new strategies for management of Alzheimer’s disease. Amer. J. Alzheimer’s disease other Dement., JMUIHS, 2010 25 (5) 414-424