Q- ABSORPTION RA TIO AND SIMULTANEOUS EQ UATION SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF FENBENDAZOLE AND NICLOSAMIDE IN PURE DRUG AND PHARMACEUTICAL FORMULATIONS-Reference-Cited by-同舟云学术

Q- ABSORPTION RA TIO AND SIMULTANEOUS EQ UATION SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF FENBENDAZOLE AND NICLOSAMIDE IN PURE DRUG AND PHARMACEUTICAL FORMULATIONS

Published:2016-01-28 Issue:01 Volume:53 Page:47-53
ISSN:0019-462X
Container-title:INDIAN DRUGS
language:
Short-container-title:IND. DRU.

Author:

Shah U,Gandhi A.,

Abstract

Two simple, accurate, sensitive and economical spectrophotometric methods have been developed and subsequently validated for determination of fenbendazole (FEN) and niclosamide (NIC) in bulk and pharmaceutical formulation. For the simultaneous equation method, the estimation of FEN and NIC was carried out at 227nm (λmax of FEN) and 332nm (λmax of NIC), respectively. For Q - absorption ratio method, estimation of FEN was carried out at 227nm (λmax of FEN) and of NIC at 306 nm (isobestic point of both drugs). Calibration curves of FEN and NIC were found to be linear in the concentration ranges of 3-9 ?g/mL and 10-30 ?g/mL, respectively, with their correlation coefficient values (r2 ) being more than 0.995. In the precision study, the % RSD value was found within limits (RSD < 2%). The percentage recovery at various concentration levels varied from 99.81 to 100 % for FEN and 99.86 to 100 % for NIC confirming that the projected methods are termed as an accurate and it can be applied successfully for the simultaneous estimation of FEN and NIC in pure and pharmaceutical dosage form.

Publisher

Indian Drug Manufacturers' Association (IDMA)

Subject

Drug Discovery,Pharmaceutical Science,Pharmacology

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