EXPLORING THE POTENTIAL OF ORODISPERSIBLE TABLET OF ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE DRUG COMBINATION

Abstract

The objective of the present work was to formulate and evaluate orodispersible tablets of enalapril maleate and hydrochlorothiazide combination to overcome the shortcomings of conventional dosage forms and improve patient compliance. Eleven formulations were prepared by wet granulation method using sodium starch glycolate as superdisintegrant and microcrystalline cellulose and Pearlitol 200 SD as diluents. The process variables were optimized to get desired characteristics. Various pre-compression and post-compression quality control parameters were evaluated. The wetting and disintegration times of formulation F10 were found to be 11 ± 4 and 15 ± 2 seconds, respectively. The in vitro dissolution study showed 97.2 % release of enalapril maleate and 96.94 % release of hydrochlorothiazide within 10 min. The optimized formulation was found to be stable during stability study. The study concludes that orodispersible tablet of enalapril maleate and hydrochlorothiazide could be a better approach for the treatment of hypertension.