Author:
Beere Nagaraju,K.V. Anil Kumar
Abstract
To establish the safety and efficacy of drug-drug combinations in diabetic hypertensive patients, the present study was designed to identify the pharmacodynamic and pharmacokinetic influence of olmesartan on glimepiride + metformin combination in normal rats, diabetic rats and normal rabbits using treatment of single and multiple doses. Blood samples were analyzed for blood glucose by GOD/POD method, insulin by elISA and serum glimepiride levels by HPlC method at pre-determined time intervals. Olmesartan showed significant synergistic hypoglycemic activity with glimepiride + metformin as well as elevated serum insulin levels in single and multiple-dose combinations in both rats and rabbits. The pharmacokinetic interactions of this combination are evidenced by a significant increase in AUMC0-t, AUMC0-∞ and MRT and there is a decrease in clearance (Cl) of glimepiride + metformin with single and multiple-dose treatment of olmesartan. Hence, care must be taken by physicians while prescribing olmesartan and glimepiride + metformin combination in a clinical situation.
Publisher
Indian Drug Manufacturers' Association (IDMA)
Subject
Drug Discovery,Pharmaceutical Science,Pharmacology
Reference30 articles.
1. 1. Santosha Vooradi, Leelavathi DA, Shubha Seshadri, Thunga G and Vijayanarayana K. Preparation, Validation and User-testing of Patient Information Leaflets on Diabetes and Hypertension. Indian J Pharm Sci. 2018; 80(1):118-25.
2. 2. Ferranti SD, Boer IH, Fonseca V. Type 1 diabetes mellitus and cardiovascular disease: a scientific statement from the American Heart Association and American Diabetes Association. Circulation. 2014; 130:1110-30.
3. 3. Paul M, Poyan Mehr A, Kreutz R. Physiology of local renin angiotensin systems. Physiol Rev. 2006; 86:747-803.
4. 4. Maggioni AP. Efficacy of Angiotensin receptor blockers in cardiovascular disease. Cardiovasc Drugs Ther. 2006; 20(4):295-308.
5. 5. Beere Nagaraju, Anil kumar KV, Ramachandra Setty S, Ravindran M, Shekar HS, Sreemantula Satyanarayana, Padmavathi GV. Patterns of antihypertensive mono therapy in hypertensive type-2 diabetics on glimepiride metformin combination. Inter. J. of Pharmacotherapy. 2016; 6(1):19-23.