SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF PIPERAZINE ANALOGUES CONTAINING [1, 3, 4]-OXADIAZOLE RING-Reference-Cited by-同舟云学术

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF PIPERAZINE ANALOGUES CONTAINING [1, 3, 4]-OXADIAZOLE RING

Published:2020-01-28 Issue:01 Volume:57 Page:19-26
ISSN:0019-462X
Container-title:INDIAN DRUGS
language:
Short-container-title:IND. DRU.

Author:

Kottakki Naveen Kumar¹,P V D Soujanya Kumari²,G Gopi³,Rao Amperayani Karteek,Parimiuma Devi

Affiliation:

1. Department of Chemistry, GITAM University, Visakhapatnam-45, Andhra Pradesh. India

2. 2Department of Microbiology, M.V.R Degree and PG College, Visakhapatnam-26, Andhra Pradesh, India

3. 3Department of Chemistry, GVP Degree and PG College, Visakhapatnam-45, Andhra Pradesh, India.

Abstract

A new series of piperazine-1, 3, 4-oxadiazole deviatives were synthesized by the condensation of 1, 3, 4-thidaizole with substituted piperazine, in the presence of N, N-diisopropylethylamine. The structures were confirmed by IR, 1H NMR, 13C NMR and Mass spectroscopy. All the precursors were screened for anti-bacterial activity and the results indicate that phenyl substituted chloro (PO2) and hydroxy (PO6) functional derivatives possess better anti-bacterial activity towards to Gram-positive bacteria and gram-negative bacteria, Maximum zone of inhibition was observed in (PO2) against Bacillus subtillus (14.0 mm) and (PO6) against Pseudomonas aeruginosa (14.0 mm). Piperazine-1, 3, 4-oxadiazoles were synthesized by combining two active molecules into a new bioactive conjugate molecule. These new hybrid molecules have more potential biological activity than their parent molecules.

Publisher

Indian Drug Manufacturers' Association (IDMA)

Subject

Drug Discovery,Pharmaceutical Science,Pharmacology

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